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I am a molecular neurobiologist interested in understanding ­the mechanisms that underlie aging and neurodegeneration. My work uses the power of Drosophila melanogaster genetics coupled with an array of molecular, cellular, behavioural, imaging and bioinformatics approaches to better understand the molecular processes that define normal aging and identify how these processes are altered in pathological aging and neurodegenerative diseases.

Molecular Biology | Animal models | Neurodegeneration |Aging | Alzheimer's Disease

We are interested in understanding selective vulnerability of neurons to pathogenic proteins such as the tangle-forming protein, tau, in Alzheimer's Disease.  This involves characterising neuronal vulnerability to tau variants and identifying genes that may mediate vulnerability or resistance to tau. 

2025

• Cyhoeddwyd
  Price, R., Ramirez-Moreno, M., Cooper, A., Singh, R., Khaw, Y. M., Mhaka, A. M., Sivanantharajah, L. & Mudher, A., 3 Meh 2025, Yn: Expert Opinion on Drug Discovery. 20, 6, t. 721-734 14 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Sivanantharajah, L., Mudher, A. & Shepherd, D., 5 Ebr 2025, Yn: Translational Psychiatry. 15, 127.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2023

• Cyhoeddwyd
  Stubbs, K., Batchelor, B., Sivanantharajah, L., Sealey, M., Ramirez-Moreno, M., Ruiz, E., Richardson, B., Perry, V. H., Newman, T. A. & Mudher, A., Ebr 2023, Yn: Brain Communications. 5, 2, fcad052.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2022

• Cyhoeddwyd
  Sivanantharajah, L. & Mudher, A., 19 Mai 2022, Yn: Frontiers in Pharmacology. 13, 903119.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2019

• Cyhoeddwyd
  Sivanantharajah, L., Mudher, A. & Shepherd, D., 1 Mai 2019, Yn: Journal of Neuroscience Methods. 319, May, t. 77-88 12 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2015

• Cyhoeddwyd
  Sivanantharajah, L. & Zhang, B., Medi 2015, Yn: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 201, 9, t. 895-909 15 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Sivanantharajah, L. & Percival-Smith, A., 1 Chwef 2015, Yn: Development Biology. 398, 1, t. 1-10 10 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid

2014

• Cyhoeddwyd
  Sivanantharajah, L. & Percival-Smith, A., 1 Mai 2014, Yn: G3: Genes, Genomes, Genetics. 4, 5, t. 829-838
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2013

• Cyhoeddwyd
  Percival-Smith, A., Sivanantharajah, L., Pelling, J. J. H. & Teft, W. A., Tach 2013, Yn: Development genes and evolution. 223, 6, t. 375-387 13 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2009

• Cyhoeddwyd
  Sivanantharajah, L. & Percival-Smith, A., 1 Mai 2009, Yn: Genetics. 182, 1, t. 191-203 13 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2025

• Platform Session: Disease Models

  Oral Presentation

  20 Meh 2025

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)

2024

• Outreach event at which we will showcase the use of the fruit fly for research at the Association for the Study of Animal Behaviour (ASAB) booth at the Wrexam Science Festival.

  4 Awst 2024

  Gweithgaredd: Mathau o waith ymgysylltu â'r cyhoedd a gwaith maes - Erthygl neu gyfranogiad yn y cyfryngau (Cyfrannwr)

• Talk entitled "Understanding the nature of selective neuronal vulnerability to tau-mediated toxicity"

  26 Meh 2024

  Cysylltau:

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)

• The UK’s largest dementia research conference taking place at the ACC in Liverpool Alzheimer’s Research UK Conference provides a fantastic chance to gain insights from colleagues working across basic, translational and clinical dementia research.

  20 Maw 2024 – 21 Maw 2024

  Cysylltau:

  Gweithgaredd: Cymryd rhan mewn cynhadledd Academaidd (Siaradwr)

• 2024

  Gweithgaredd: Mathau o waith ymgysylltu â'r cyhoedd a gwaith maes - Erthygl neu gyfranogiad yn y cyfryngau (Cyfrannwr)

• 01/06/2022 – 30/06/2026 (Wrthi'n gweithredu)

• 01/04/2021 – 31/10/2021 (Wedi gorffen)

• 12/01/2017 – 31/07/2023 (Wedi gorffen)