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I am a molecular neurobiologist interested in understanding ­the mechanisms that underlie aging and neurodegeneration. My work uses the power of Drosophila melanogaster genetics coupled with an array of molecular, cellular, behavioural, imaging and bioinformatics approaches to better understand the molecular processes that define normal aging and identify how these processes are altered in pathological aging and neurodegenerative diseases.

Molecular Biology | Animal models | Neurodegeneration |Aging | Alzheimer's Disease

We are interested in understanding selective vulnerability of neurons to pathogenic proteins such as the tangle-forming protein, tau, in Alzheimer's Disease.  This involves characterising neuronal vulnerability to tau variants and identifying genes that may mediate vulnerability or resistance to tau. 

2025

• Published
  Price, R., Ramirez-Moreno, M., Cooper, A., Singh, R., Khaw, Y. M., Mhaka, A. M., Sivanantharajah, L. & Mudher, A., 3 Jun 2025, In: Expert Opinion on Drug Discovery. 20, 6, p. 721-734 14 p.
  Research output: Contribution to journal › Article › peer-review
• Published
  Sivanantharajah, L., Mudher, A. & Shepherd, D., 5 Apr 2025, In: Translational Psychiatry. 15, 127.
  Research output: Contribution to journal › Article › peer-review

2023

• Published
  Stubbs, K., Batchelor, B., Sivanantharajah, L., Sealey, M., Ramirez-Moreno, M., Ruiz, E., Richardson, B., Perry, V. H., Newman, T. A. & Mudher, A., Apr 2023, In: Brain Communications. 5, 2, fcad052.
  Research output: Contribution to journal › Article › peer-review

2022

• Published
  Sivanantharajah, L. & Mudher, A., 19 May 2022, In: Frontiers in Pharmacology. 13, 903119.
  Research output: Contribution to journal › Article › peer-review

2019

• Published
  Sivanantharajah, L., Mudher, A. & Shepherd, D., 1 May 2019, In: Journal of Neuroscience Methods. 319, May, p. 77-88 12 p.
  Research output: Contribution to journal › Article › peer-review

2015

• Published
  Sivanantharajah, L. & Zhang, B., Sept 2015, In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 201, 9, p. 895-909 15 p.
  Research output: Contribution to journal › Review article › peer-review
• Published
  Sivanantharajah, L. & Percival-Smith, A., 1 Feb 2015, In: Development Biology. 398, 1, p. 1-10 10 p.
  Research output: Contribution to journal › Review article › peer-review

2014

• Published
  Sivanantharajah, L. & Percival-Smith, A., 1 May 2014, In: G3: Genes, Genomes, Genetics. 4, 5, p. 829-838
  Research output: Contribution to journal › Article › peer-review

2013

• Published
  Percival-Smith, A., Sivanantharajah, L., Pelling, J. J. H. & Teft, W. A., Nov 2013, In: Development genes and evolution. 223, 6, p. 375-387 13 p.
  Research output: Contribution to journal › Article › peer-review

2009

• Published
  Sivanantharajah, L. & Percival-Smith, A., 1 May 2009, In: Genetics. 182, 1, p. 191-203 13 p.
  Research output: Contribution to journal › Article › peer-review

2025

• Platform Session: Disease Models

  Oral Presentation

  20 Jun 2025

  Activity: Oral presentation (Speaker)

2024

• Outreach event at which we will showcase the use of the fruit fly for research at the Association for the Study of Animal Behaviour (ASAB) booth at the Wrexam Science Festival.

  4 Aug 2024

  Activity: Types of Public engagement and outreach - Media article or participation (Contributor)

• Talk entitled "Understanding the nature of selective neuronal vulnerability to tau-mediated toxicity"

  26 Jun 2024

  Links:

  Activity: Oral presentation (Speaker)

• The UK’s largest dementia research conference taking place at the ACC in Liverpool Alzheimer’s Research UK Conference provides a fantastic chance to gain insights from colleagues working across basic, translational and clinical dementia research.

  20 Mar 2024 – 21 Mar 2024

  Links:

  Activity: Participation in Academic conference (Speaker)

• 2024

  Activity: Types of Public engagement and outreach - Media article or participation (Contributor)

• 01/06/2022 – 30/06/2026 (Active)

• 01/04/2021 – 31/10/2021 (Finished)

• 12/01/2017 – 31/07/2023 (Finished)